For fun I made an Irssi script that makes use of the automeme.net API. Personally I’ve been using rupa’s automeme bash script, though I made an Irssi alternative for a friend that uses Irssi+cgywin.
Example:
[04:06:18] <~newton> I MOONWALK, THEREFORE I SUCK. [04:06:19] <~newton> IS IT CAN BE ESKIMOS TIEM NAO PLEES? [04:06:20] <~newton> BECOME AN HACKERS ON STEROIDS
You can grab it from http://sindacio.us/irssi/automeme.txt.
I’ll also note this is the first Irssi/Perl script I’ve ever made.